YHK - yet another hacker news clone

I did try keto before. Heavy protein, low carbs. Everyone promised a high protein/fat/fiber diet with low starch/sugar was the secret to feeling full sooner and for longer.

Nope. Didn't change a damn thing. I was still hungry all the time.

My experience mirrors the GP. Ozempic really flipped the switch. See my other comment (https://news.ycombinator.com/item?id=50399564) for more.

These GLP 1 drugs are huge molecules with a GLP 1 shaped key on them. It's like a house key attached to a school bus. Once it's in your lock, that key is going to be a pain to remove.

Stimulating natural GLP 1 helps for a few minutes. Using these drugs can help for a week.

If you ever tried water fasting first couple of days are gruelling but day 3 and 4 are significantly easier. Another natural hunger suppressant is cardio which reduces hunger.

Good news: they let the patent on Semaglutide lapse in Canada, and it’s already expired naturally in India and a bunch of South American countries. There are going to be accessible generics at some point.

I've come to realize that some of this difference actually comes from low-effort activity like walking.

At 1796 kcal BMR your weight is 76 kg.

At 1896 kcal BMR your weight is 86 kg.

At 1996 kcal BMR your weight is 96 kg.

It is easier to just eat 100 kcal less, but it's also not unreasonable for people to walk more. 100 kcal gets burned in something like 30-60 minutes of walking.

And that 100 kcal is a 10 kg difference in weight in the long-term (22 lbs). The key is that people usually don't go for those walks to lose weight, they just happen naturally during their day due to other reasons.

The looking down on people is the huge problem. It is at least in part a self control problem, and also who cares? Everyone has things they try to deal with, faults they don't even notice, etc.

In my opinion, saying it is often a self-control problem is calling a spade a spade. It isn't always that, there are other reasons people may struggle with obesity. But for those finding help in GLP-1 blockers it does seem to boil down to just eating less. And again, who cares? Demonizing and shaming people for lacking self-control in certain areas is just a pretty shitty way to treat people.

I find the treatment that got approved for its effect on hunger last year interesting. It's a completely different drug to semaglutide and its analogs. Quick search suggests that it's seemingly not as effective for ordinary obesity, but substantially more effective for this specific syndrome, and vice versa.

So while your body produces it in a few places, the product gets used up almost immediately.

https://www.hsalist.org/tools/satiety-index/

I've not found any promising leads, besides maybe something fuzzy about intestinal microbiome. But I've not given up hope of figuring it out.

Especially, I'd note that if a food production company had accidentally added, say a GLP-1 antagonist (without knowing what it was) to their product, they'd just notice sales go up and consider it quite good business.

Now, if you remove breads, sugars, and processed foods, try eating the same number of calories with whole foods only. You’ll become full way before you reach that number.

And some people, like your wife, simply respond to food differently. Id say she’s in the minority, though.

I, like yourself and most people, don’t feel full until I’ve eaten an unreasonable amount of certain types of foods. Since switching to Whole Foods and cutting out breads, sugars, and processed foods, I’ve lost weight while eating until I’m full/satisfied.

Yes?

When you hit the puberty your requirements go up for an additional 1000-1500 calories.

Women calorie demand returns back after puberty, men stays the same and the calorie burn rate (if you don't sit 24/7 at the screen ofc) are higher than a women' one in the first place. So you on all levels - including your own habits - are conditioned to eat a whole lot.

And then your forties come your body suddenly decides what you don't need that much energy and your metabolism slows down, winding down the calorie intake demands. But if all your life you needed a whole chicken with a plate to 'feel full' then you won't suddenly eat a couple of chicken wings and have a 'feel full' feeling.

And I would agree with a sibling comment: the food caloric density did increased a lot though 'saltier, sweeter, and generally more addictive' is not a rule but a more of a diet choices.

It's hard to estimate how much the last couple of generations weight was because of smoking cigarettes suppressed appetite too

as a skinny person for most of my life, and someone who wakes up famished in the mornings, very eager to eat breakfast, this is patently false.

but I do agree that it's a miracle cure for those who struggle with constant hunger.

If GLP-1 blockers work for people then great, but it does so by making them uninterested in eating, meaning all those years of people being demonized for saying obesity is, in some meaningful part, a lack of will power and self control were indeed right. If it was either of those, and instead obesity is a purely genetic condition, appetite suppression wouldn't help.

I suspect it’s a touch more complex than that. :)

Anecdata: I have a 40-something friend who enjoys eating lots more than I do (and I witness this repeatedly: round after round of bread and chunks of cheese after a full meal, always happy to have desserts that I’ll sometimes forgo, etc.) and who stays slim. Sure, he exercises, but not so much more than I do to account for the calorie delta between us.

He’s just made differently, in a way we can’t currently explain. We sometimes joke about a faecal transplant.

One of the worst outcomes from GLP-1 drugs are people getting on them and then saying ridiculous things like this. Just totally confident that they can discount other folks lived experiences.

I know quite a few skinny people who have struggled every single day with food noise, overeating, and self control. They simply got through it with a lot of struggle, habits, and discipline.

Some of these people had to maintain their weight and fitness because their careers required looking conventionally attractive for their jobs. It consumed most of their life doing so. Some of these folks are now on GLP-1s and their lives are immensely better as they don't need to constantly be in a battle of willpower with themselves.

There are a huge number of "skinny" people out there who feel hunger in very likely the same way many obese people do.