YHK - yet another hacker news clone

Novo Nordisk, Eli Lilly Report GLP-1 Signals of Slowed Biological Aging at ARDD

27 points hnburnsy 1 hour ago 11 comments

ChrisArchitect 1 hour ago | parent

Related:

GLP-1 may slow biological aging

https://news.ycombinator.com/item?id=50132328

xnx 48 minutes ago | parent

Many here have expressed skepticism at GLP1s because they don't require the personal discipline of caloric deficit and might have unknown side effects.

So far, all the unknown side effects I've read about have been like this.

andreshb 36 minutes ago | parent

Lawsuits claiming Ozempic, other GLP-1s led to blindness become second mass litigation over the drugs

https://www.reuters.com/legal/government/lawsuits-claiming-o...

ipsum2 36 minutes ago | parent

This is from a year ago. Millions of people are on GLP-1s, there's definitely not a mass blindness that's ongoing.

declan_roberts 28 minutes ago | parent

Not to mention the first people on these drugs were type 2 diabetics who are the exact group that's at risk for NEON.

Think of all the things they're not gonna be at risk for, not being diabetic now.

annzabelle 22 minutes ago | parent

N of 1, but I had serious low drive/motivation side effects from Wegovy. Everything enjoyable became less enjoyable, from alcohol, to running, and after a couple of months, even getting out of bed. I lost weight slower than I had previously with old school calorie counting (most of which I have kept off to this day). Within a couple weeks of getting off it I was back to normal.

My conspiracy theory is that a lot of people must be getting this global lowered reward sensitivity from GLP-1s but are ignoring the negative sides of that effect because they like being skinny.

lucianmarin 22 minutes ago | parent

It's not the caloric deficit, it's the insulin. Cells don't have caloric receptors, only insulin receptors. I created an info site about this. Managing your insulin have the same effects as GLP-1 meds.

metadat 12 minutes ago | parent

Why mention your info site without providing a link? It's a little frustrating to read comments like this. Thank you.

dcrazy 6 minutes ago | parent

I’ve seen headlines about a potential link to hair loss lately.

nozzlegear 44 minutes ago | parent

Sign me up for this miracle drug already.

declan_roberts 20 minutes ago | parent

I suspect that there's twice as many people taking RUO versions of it than actual prescriptions.

You can get the stuff at a mall kiosk now.